CELL-SPECIFIC MONITORING OF PROTEIN SYNTHESIS IN VIVO.

Cell-specific monitoring of protein synthesis in vivo.

Analysis of general and specific protein synthesis provides important information, relevant to cellular physiology and function.However, existing methodologies, involving metabolic labelling by incorporation of radioactive amino acids into nascent polypeptides, cannot be applied to monitor protein synthesis in specific cells or tissues, in read mor

read more

Ignition mechanism and chemical reaction of the micro-damage polymer-bonded explosives under different inertial loading conditions

Understanding the impact-induced ignition properties and energy release behavior of polymer-bonded explosives (PBXs) is critical for the safety of explosive systems.In this study, a new impact test component was designed using a light gas gun to quantify the ignition mechanism and chemical reaction of micro-damaged PBXs under different inertial loa

read more


Molecular optimization using a conditional transformer for reaction-aware compound exploration with reinforcement learning

Abstract Designing molecules with desirable properties is a critical endeavor in drug discovery.Because of recent advances in deep learning, molecular generative models have been developed.However, the existing compound exploration models often disregard the important issue of ensuring the apac1/60/1/cw feasibility of organic synthesis.To address t

read more